Chromium nicotinate (polynicotinate)
What it is
Chromium bound to niacin rather than picolinic acid, retaining chromium's glucose/insulin effects while avoiding theoretical picolinate concerns around oxidative DNA damage seen in some in-vitro work. Polynicotinate has similar absorption to picolinate but may be more stable in gut. Evidence for glycaemic benefit is modest at best in people without clear chromium deficiency. A reasonable alternative form for those worried about picolinate or already taking niacin. Avoid above 1000 mcg/day chronically.
Dose
100–400 mcg elemental chromium as polynicotinate daily
Time of day & tips
Take with a carbohydrate-containing meal; effect size is small and inconsistent in trials; do not combine with high-dose niacin (duplicate niacin exposure); discontinue if no effect at 12 weeks
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