Chasteberry/Vitex standardised (BNO 1095)
What it is
The standardised extract BNO 1095 has the strongest evidence among Vitex preparations for PMS. Pivotal RCTs of the BNO 1095 extract (Loch 2000, Schellenberg 2001 BMJ, and later replications) confirmed significant reductions in irritability, mood swings, breast tenderness, and bloating. Works by modulating dopamine and prolactin signalling. Takes 2–3 cycles to reach full effect. Avoid with dopamine agonists or oral contraceptives.
Dose
20 mg/day BNO 1095 extract or 4 mg/day Ze 440 extract; take continuously through the full cycle
Time of day & tips
Take every morning continuously — not just during PMS days. Allow 2–3 full menstrual cycles for maximum benefit. Avoid with oral contraceptives, HRT, or dopamine medications. Morning dosing is traditional.
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