50
SCORE
Calcium alpha-ketoglutarate (Ca-AKG)
Longevity · Mitochondrial · Bone
Tier 3 — Trending
What it is
Calcium salt of alpha-ketoglutarate, a Krebs-cycle intermediate. Animal data including a notable mouse longevity study show extended median lifespan and reduced frailty. Small human trials suggest improvements in biological-age markers, with the Buck Institute / Ponce de Leon Health work being the most-cited human dataset. Evidence remains preliminary and product quality varies widely.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
1/5
Cost
2/5
Drug-int.
4/5
Dose
1,000–2,000 mg/day Ca-AKG with food
Time of day & tips
Provides modest dietary calcium — factor into total intake; long-term human safety data are limited; expensive relative to evidence strength.
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