65
SCORE
Butyrate (calcium/magnesium)
Gut barrier · IBD · Microbiome
Tier 2 — Promising
What it is
A short-chain fatty acid produced by gut bacteria fermenting fibre. Supplemental butyrate (calcium or magnesium salt) supports gut barrier integrity and reduces intestinal inflammation. Small trials show benefit in ulcerative colitis and IBS. Enteric-coated capsules preferred for colonic delivery. Has an unpleasant odour — keep container tightly sealed.
Efficacy
3/5
Safety
4/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
5/5
Dose
300–1,200 mg/day calcium or magnesium butyrate; enteric-coated for colonic delivery
Time of day & tips
Take 2–3× daily with meals. Use enteric-coated capsules for colonic delivery. Uncoated versions have a very unpleasant smell — keep tightly sealed.
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →