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Butyrate tributyrin (odourless)

Gut integrity · Colon health · Microbiome
Tier 2 — Promising

What it is

Tributyrin delivers butyrate to the colon where it fuels colonocytes and maintains gut barrier integrity. More stable and odourless than sodium butyrate, with less small-intestine degradation. Small human trials (Banasiewicz 2013 and others) suggest butyrate/tributyrin improves gut permeability markers and symptoms in IBD and IBS, though most evidence remains preliminary. Well tolerated.

Efficacy
3/5
Safety
4/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
5/5

Dose

300–600 mg/day tributyrin; better colon delivery and palatability than sodium butyrate powder

Time of day & tips

Take with meals. Tributyrin capsules are odourless — an advantage over sodium butyrate. Start at 300 mg and increase after one week. No significant drug interactions.

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