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Boswellic acids AKBA (standardised)

Joint pain · IBD · 5-LOX inhibitor

Tier 2 — Promising

What it is

The most potent fraction of Boswellia serrata, acetyl-11-keto-beta-boswellic acid (AKBA), specifically inhibits 5-LOX inflammation without affecting COX pathways. A 2025 review ranked Boswellia first among natural joint supplements for knee osteoarthritis pain. Higher AKBA content distinguishes premium from low-quality extracts. Better tolerated than NSAIDs with no GI bleeding risk.

Efficacy

3/5

Safety

4/5

Research

3/5

Onset

2/5

Cost

3/5

Drug-int.

4/5

Dose

100–300 mg/day AKBA (look for extracts standardised to 30% AKBA); take with a fat-containing meal

Time of day & tips

Always take with a fat-containing meal — fat doubles boswellic acid absorption. Allow 6–8 weeks to judge effectiveness. Look for AKBA-standardised products, not generic Boswellia.

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