Borage oil (GLA)
What it is
Borage seed oil is the highest-GLA (gamma-linolenic acid) commercial source at roughly 20-24% GLA — approximately 2-3x evening primrose oil. GLA bypasses the rate-limiting delta-6-desaturase step and feeds into anti-inflammatory series-1 prostaglandins. Evidence is modest for atopic dermatitis, rheumatoid arthritis, and diabetic neuropathy. Contains small amounts of pyrrolizidine alkaloids (PAs) — use only products certified PA-free for long-term use. Not a direct EPA/DHA substitute.
Dose
1000–3000 mg borage oil daily (providing 240–720 mg GLA)
Time of day & tips
Use only PA-free certified products; take with meals; effects on skin/joints take 6-12 weeks; combine with fish oil to prevent arachidonic-acid buildup from GLA
Compare or learn more
Compare with another supplement →
Browse by symptom →
Open the full interactive view →