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SCORE
Benfotiamine (fat-soluble B1)
Neuropathy · AGE prevention · B1 bioavailability
Tier 2 — Promising
What it is
A fat-soluble thiamine precursor achieving blood levels up to 5 times higher than standard thiamine and entering nerve and brain tissue far more effectively. Multiple trials confirm it reduces diabetic nerve pain and prevents advanced glycation end-products linked to aging-related tissue damage. Preferred for neuropathy.
Efficacy
3/5
Safety
5/5
Research
3/5
Onset
3/5
Cost
4/5
Drug-int.
5/5
Dose
150–300 mg/day for neuropathy and AGE prevention; take with food as it is fat-soluble
Time of day & tips
Take with food to ensure fat-soluble absorption. Split into morning and evening doses for neuropathy. Does not turn urine bright yellow like standard water-soluble B vitamins.
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