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Bacillus clausii

Probiotic · Antibiotic-associated diarrhoea

Tier 2 — Promising

What it is

A spore-forming probiotic (Enterogermina) used extensively in Europe, India, and Latin America for antibiotic-associated diarrhoea, paediatric diarrhoea, and IBS. Survives simultaneous antibiotic exposure due to intrinsic resistance to common antibiotics — making it uniquely suitable for concurrent use with antibiotics. Multiple RCTs support benefit in children and adults for acute diarrhoea. Naturally antibiotic-resistant strains theoretically raise horizontal-transfer concerns, though no clinical problems have emerged in decades of use.

Efficacy

3/5

Safety

4/5

Research

3/5

Onset

4/5

Cost

3/5

Drug-int.

4/5

Dose

2–6 billion spores daily, taken in 1–3 divided doses with or without food. Often dispensed as 5-mL liquid vials in Europe/India.

Time of day & tips

Can be taken concurrently with antibiotics (unlike most probiotics); often dispensed as liquid vials in Europe/India; particularly well-tolerated in children

Sensitive populations: This supplement's evidence base touches pregnancy, pediatric, or other sensitive populations. Confirm any change with your healthcare provider before use.

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