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B-complex (balanced)

Multi-B vitamin · Energy · Methylation
Tier 2 — Promising

What it is

A balanced combination of all eight B vitamins in doses close to nutritional requirements (not the megadoses common in energy drinks). B-complex is the default supplemental approach when a single B deficiency is suspected but uncertain, since B vitamins act cooperatively and isolated high-dose single-B supplementation can unmask or worsen deficits in others. Activated (methyl/P5P/benfotiamine) versions are preferred over cheap forms (cyanocobalamin, folic acid, pyridoxine HCl) for genetic variants and long-term use.

Efficacy
3/5
Safety
5/5
Research
3/5
Onset
3/5
Cost
5/5
Drug-int.
4/5

Dose

1 activated B-complex capsule/day with breakfast (doses vary by product)

Time of day & tips

Prefer methylfolate + methylcobalamin + P5P forms; take with breakfast to avoid sleep disruption from B6/B12; urine will turn bright yellow (harmless, riboflavin)

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