58
SCORE
Alpha-Lipoic Acid (ALA)
Diabetic neuropathy · Antioxidant
Tier 3 — Trending
What it is
Reduces nerve pain (numbness, tingling, burning) from diabetic neuropathy — confirmed by multiple reviews. Uniquely antioxidant in both water and fat. Lowers blood sugar — hypoglycemia risk with diabetes medications. NIH warns high doses (>1,200 mg/day) may reduce thyroid hormone levels. Use the R-ALA form; it is more potent than the racemic form.
Efficacy
3/5
Safety
3/5
Research
3/5
Onset
2/5
Cost
3/5
Drug-int.
3/5
Dose
600 mg/day R-ALA (or 1,200 mg/day racemic ALA); take 30 min before meals; caution with diabetes medications
Time of day & tips
Take 30 min before meals on an empty stomach for best absorption. Monitor blood sugar closely if on diabetes medication. Avoid doses above 1,200 mg/day — thyroid risk.
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