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SCORE
Activated B complex (methylated)
Energy · Mood · Methylation
Tier 3 — Trending
What it is
A B-complex formula using pre-methylated forms (methylfolate, methylcobalamin, P5P) that bypass the MTHFR enzyme. Clinical benefit is clearest for people with confirmed MTHFR mutations and elevated homocysteine. Most healthy adults absorb standard B vitamins effectively and gain little advantage from the more expensive methylated versions. Avoid late-day dosing.
Efficacy
2/5
Safety
4/5
Research
2/5
Onset
3/5
Cost
3/5
Drug-int.
4/5
Dose
1 capsule/day providing methylated B12, folate, and B6 (P5P); most useful with confirmed MTHFR variants
Time of day & tips
Take in the morning with water and food. Avoid taking in the evening — B vitamins can be energising and may disrupt sleep.
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