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Supplements for skin, hair, and nails

Collagen peptides, biotin, and the ones that actually move the needle.

Collagen peptides (10–15 g + vitamin C cofactor) have 13+ trials supporting skin elasticity and joint comfort over 3+ months. Biotin shows hair effects only in actual deficiency; mega-dose biotin distorts thyroid lab tests. Niacinamide topically (and orally for some indications) is well-evidenced. Vitamin D3 if deficient improves skin barrier. Astaxanthin has small skin-photoprotection trials. Most 'beauty blends' rely on collagen + small amounts of cofactors — pay for the collagen, not the marketing.
78
Glycine
Sleep · Collagen synthesis · Metabolic
Tier 2
77
Acerola cherry extract
Immunity · Antioxidant · Skin · Vitamin C
Tier 2
76
Vitamin C (moderate dose)
Immunity · Collagen · Antioxidant
Tier 2
76
Carnosyn beta-alanine (sustained release)
Performance · Endurance · Muscle endurance
Tier 2
75
Collagen peptides
Skin · Joint · Connective tissue
Tier 1
74
Biotin (low-dose, deficiency)
Hair · Nails · Metabolism
Tier 2
74
Niacinamide (nicotinamide)
Knee OA · NAD precursor · Skin · No flush · B3 form
Tier 2
74
Calcium pantothenate (Vitamin B5)
Vitamin B5 · Adrenal · Skin
Tier 2
73
Vitamin A (retinol, low-dose)
Vision · Immunity · Skin
Tier 2
71
Beta-Alanine
Endurance · High-intensity
Tier 2
70
Lycopene
Prostate · Cardiovascular · Skin
Tier 2
70
Collagen peptides (type I, exercise recovery)
Tendon · Ligament · Exercise recovery
Tier 2
70
Eggshell membrane (NEM)
Joint · Connective tissue · Collagen
Tier 2
69
Proline (L-Proline)
Collagen synthesis · Wound healing · Skin
Tier 2
68
Pantothenic acid (Vitamin B5)
Energy · Adrenal support · Skin
Tier 2
68
Zeaxanthin (standalone)
Eye health · Macular pigment · AMD
Tier 2
68
Evening primrose oil (EPO)
Women's health · PMS · Skin
Tier 2
67
Marine collagen (fish-derived)
Skin · Joint · Bioavailability
Tier 2
67
Plant ceramides
Skin · Gut barrier · Hydration
Tier 2
66
L-Cysteine
Hair · Skin · Glutathione · Detox
Tier 2
64
Niacin (Vitamin B3)
Lipids · Skin · Energy metabolism
Tier 2
64
L-Lysine
Cold sores · Collagen · Immunity
Tier 2
64
Calendula (Calendula officinalis)
Wound healing · Skin · Anti-inflammatory
Tier 2
64
Ferulic acid
Antioxidant · Muscle recovery · Bone health · Coffee phenolic
Tier 2
63
Silicon (orthosilicic acid)
Bone · Hair thickness · Nails
Tier 2
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.
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