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Supplements for athletic performance

Strength, power, endurance — the supplements with real ergogenic data.

Creatine monohydrate (3–5 g/day) is the most evidence-backed legal ergogenic. Beta-alanine (3.2–6.4 g/day in divided doses) for 1–4 minute efforts. Sodium bicarbonate for similar durations. Caffeine for endurance and reaction time. Dietary nitrate / beetroot for endurance. Citrulline malate for blood-flow and reps. Whey protein for muscle protein synthesis (0.4 g/kg per meal). HMB or leucine helps older adults preserve muscle. Tart cherry for soreness. Most 'pre-workout' blends with proprietary formulas don't add to this list.
98
Electrolyte replacement (clinical)
Hydration · Exercise · Heat illness
Tier 1
96
Creatine monohydrate
Performance · Cognition
Tier 1
92
Caffeine (standardised)
Performance · Alertness · Endurance
Tier 1
92
Protein supplementation (clinical sarcopenia)
Muscle · Aging · Sarcopenia
Tier 1
90
Electrolyte complex (Na/K/Mg)
Hydration · Performance · Recovery
Tier 1
88
Vitamin B1 (Thiamine, clinical)
Neurology · Alcohol recovery · Energy
Tier 2
88
L-Leucine (standalone)
Muscle protein synthesis · mTOR · Sarcopenia · Leucine threshold
Tier 1
86
Vitamin B2 (Riboflavin low-dose)
Energy metabolism · Cellular function · B2
Tier 2
84
Whey protein
Muscle synthesis · Sarcopenia
Tier 1
84
Sodium bicarbonate (sports)
Buffering · Endurance · Sprint
Tier 2
83
Vitamin D3
Bone · Immunity · Muscle
Tier 1
82
Sodium bicarbonate (exercise buffer)
Performance · Acid buffering · Endurance
Tier 2
80
Calcium
Bone · Muscle · Nerve
Tier 1
80
L-Carnitine
Male fertility · Cardiac · Fat metabolism · Exercise recovery
Tier 1
79
Calcium carbonate/citrate (bone health)
Bone density · Osteoporosis · Pregnancy
Tier 1
76
Citrulline malate
Muscular endurance · Blood flow
Tier 1
76
Tyrosine (L-tyrosine)
Focus · Stress resilience · Cognition
Tier 2
76
Carnosyn beta-alanine (sustained release)
Performance · Endurance · Muscle endurance
Tier 2
76
Cluster dextrin (HBCD)
Intra-workout fuel · Endurance · Gastric emptying
Tier 2
75
Collagen peptides
Skin · Joint · Connective tissue
Tier 1
75
Pancreatin (porcine digestive enzymes)
Pancreatic insufficiency · Digestion · Fat absorption
Tier 2
74
Casein protein
Overnight muscle synthesis
Tier 1
74
EAAs (Essential amino acids)
Muscle · Recovery · Fasting
Tier 2
74
Pea protein
Muscle · Vegan protein · Satiety
Tier 2
74
Egg white protein
Muscle · Low-fat · Complete protein
Tier 2
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.
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