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Supplements for immunity

What helps a cold, what helps prevention, and what the supplement aisle gets wrong.

Zinc 13–23 mg lozenges started within 24 h of cold symptoms shorten illness by ~33% (Hemilä Cochrane). Vitamin C 1 g daily reduces cold severity and duration by ~8% (Cochrane 2013) — meaningful for athletes/cold environments, modest for general public. Vitamin D3 if deficient reduces respiratory infection rates. Elderberry has positive but limited data for cold/flu. Avoid: high-dose immune-stimulating herbs (echinacea, andrographis, mushroom polysaccharides) if you are immunosuppressed — they may counteract therapy.
90
Electrolyte complex (Na/K/Mg)
Hydration · Performance · Recovery
Tier 1
86
Saccharomyces boulardii CNCM I-745
Gut health · Antibiotic-associated diarrhoea · C. diff prevention
Tier 1
83
Vitamin D3
Bone · Immunity · Muscle
Tier 1
83
Zinc
Immunity · Cold duration
Tier 1
80
Lactobacillus rhamnosus GG
Gut · IBS · Pediatric diarrhoea
Tier 1
77
Vitamin D3 liquid drops
Bone · Immunity · Flexible dosing
Tier 2
77
Zinc picolinate
Immunity · Absorption · Taste and smell
Tier 2
77
Acerola cherry extract
Immunity · Antioxidant · Skin · Vitamin C
Tier 2
76
Vitamin C (moderate dose)
Immunity · Collagen · Antioxidant
Tier 2
76
Tyrosine (L-tyrosine)
Focus · Stress resilience · Cognition
Tier 2
76
Nicotinic acid (Niacin, flush form)
Lipids · Cardiovascular · Vitamin B3
Tier 2
75
Lactobacillus acidophilus
Gut · Vaginal health · Cholesterol
Tier 2
74
DGL Licorice (deglycyrrhizinated)
GERD · Ulcer · Gut lining
Tier 2
74
Niacinamide (nicotinamide)
Knee OA · NAD precursor · Skin · No flush · B3 form
Tier 2
73
Vitamin A (retinol, low-dose)
Vision · Immunity · Skin
Tier 2
73
Cranberry extract
UTI prevention · Bladder health
Tier 2
73
Vitamin K1 (phylloquinone)
Blood clotting · Bone health
Tier 2
73
Zinc gluconate
Zinc form · Cold duration · Immune
Tier 2
72
Saffron (Crocus sativus)
Depression · Anxiety · Cognition
Tier 1
72
Lactobacillus plantarum
Gut health · Immunity · IBS
Tier 2
72
Beta-glucan (1,3/1,6)
Immunity · Cholesterol · Gut
Tier 2
72
Zinc carnosine
Gut barrier · H. pylori · Ulcer
Tier 2
72
Bifidobacterium lactis (BB-12 / HN019)
Immunity · Gut regularity · Infant health
Tier 2
72
Lactobacillus casei Shirota
Gut · Immunity · Mood
Tier 2
72
Bifidobacterium longum BB536
Gut health · Immunity · Allergy
Tier 2
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.
See also: All symptoms · Compare two supplements · About · Methodology