Supplements for hormonal balance

Hormonal claims are where supplement marketing diverges most from clinical evidence. Real, evidence-supported interventions include: selenium + iodine for thyroid (selenium-dependent deiodinases convert T4→T3), myo-inositol for PCOS, B6 + magnesium + calcium for PMS, soy isoflavones for hot flashes (East Asian women specifically). Most testosterone-boosting supplements (tribulus, fadogia, tongkat, fenugreek) have weak or null human evidence. DIM and I3C shift estrogen metabolism but with unclear clinical effect.