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Supplements for gut health

Probiotics, prebiotics, and the fibre spectrum — what each strain actually does.

Probiotic effects are strain-specific, not generic. Lactobacillus rhamnosus GG (most-studied), Saccharomyces boulardii (only one that survives antibiotics), Bifidobacterium infantis 35624 (the IBS strain), and Lactobacillus reuteri DSM 17938 (infant colic) all have specific RCT-backed indications. Acacia fibre is the most gut-tolerant prebiotic. Psyllium has FDA health claims for both cholesterol and IBS-C. Peppermint oil (enteric-coated) is first-line for IBS in NICE guidelines. Avoid: 'multi-strain immunity blends' that don't specify strain or CFU.
94
Psyllium husk (soluble fibre)
Cholesterol · Gut regularity · Glucose
Tier 1
94
Oat beta-glucan (cholesterol)
LDL cholesterol · FDA health claim · Soluble fibre · Heart health · Evidence
Tier 2
90
Lactase enzyme
Lactose intolerance · Dairy digestion
Tier 2
89
Fibre (general dietary)
Gut · Heart · Glucose
Tier 2
86
Psyllium husk (Plantago ovata)
Cholesterol · Gut · Glucose
Tier 2
86
Saccharomyces boulardii CNCM I-745
Gut health · Antibiotic-associated diarrhoea · C. diff prevention
Tier 1
84
Whey protein
Muscle synthesis · Sarcopenia
Tier 1
82
Magnesium glycinate
Magnesium form · Sleep · Anxiety
Tier 1
80
Lactobacillus rhamnosus GG
Gut · IBS · Pediatric diarrhoea
Tier 1
80
Saccharomyces boulardii
Gut · C. diff · Traveller diarrhoea
Tier 1
79
Bifidobacterium infantis 35624
IBS · Bloating · Gut-brain axis
Tier 2
79
Magnesium citrate
Constipation · General Mg · Bioavailability
Tier 1
79
Limosilactobacillus reuteri DSM 17938
Infant colic · Gut health · Bone density
Tier 2
78
Peppermint oil (enteric-coated)
IBS · Gut motility · Pain
Tier 2
76
Resistant starch (prebiotic)
Gut microbiome · Glucose · Satiety
Tier 2
75
Lactobacillus acidophilus
Gut · Vaginal health · Cholesterol
Tier 2
75
Pancreatin (porcine digestive enzymes)
Pancreatic insufficiency · Digestion · Fat absorption
Tier 2
74
Casein protein
Overnight muscle synthesis
Tier 1
74
DGL Licorice (deglycyrrhizinated)
GERD · Ulcer · Gut lining
Tier 2
74
Egg white protein
Muscle · Low-fat · Complete protein
Tier 2
74
Chamomile extract (Matricaria chamomilla)
Anxiety · Sleep · Digestive
Tier 1
74
Lactobacillus gasseri
Weight management · Vaginal microbiome · H. pylori · Visceral fat
Tier 2
74
Acacia fiber (prebiotic)
Prebiotic · IBS · Cholesterol · Bifidobacterium · Gentle · SIBO-safe
Tier 1
72
Sunfiber (partially hydrolysed guar gum)
Gut · IBS · Prebiotic
Tier 2
72
Lactobacillus plantarum
Gut health · Immunity · IBS
Tier 2
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.
See also: All symptoms · Compare two supplements · About · Methodology