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Supplements for heart health

Cholesterol, blood pressure, and cardiovascular outcomes — by what the trials show.

Psyllium husk (FDA-recognised health claim, 7 g/day), oat beta-glucan (3 g/day), bergamot, red yeast rice (acts like a low-dose statin), and aged garlic extract have the strongest LDL-lowering evidence. Omega-3 at high dose lowers triglycerides but raises atrial-fibrillation risk by ~50% (O'Keefe 2024) — discuss with cardiology. Magnesium, hibiscus, hawthorn, and beetroot have BP-lowering data. CoQ10 ubiquinol is reasonable when on statins (statins deplete it).
94
Psyllium husk (soluble fibre)
Cholesterol · Gut regularity · Glucose
Tier 1
94
Oat beta-glucan (cholesterol)
LDL cholesterol · FDA health claim · Soluble fibre · Heart health · Evidence
Tier 2
89
Fibre (general dietary)
Gut · Heart · Glucose
Tier 2
86
Psyllium husk (Plantago ovata)
Cholesterol · Gut · Glucose
Tier 2
86
Vitamin B1 (Thiamine)
Nerve function · Energy metabolism · Deficiency
Tier 2
82
Magnesium
Sleep · Cognition · Metabolic
Tier 1
81
Potassium supplementation (clinical)
Blood pressure · Cardiovascular · Electrolyte
Tier 1
80
Calcium
Bone · Muscle · Nerve
Tier 1
80
L-Carnitine
Male fertility · Cardiac · Fat metabolism · Exercise recovery
Tier 1
79
Omega-3 (EPA/DHA)
Cardiovascular · Inflammation
Tier 1
79
Calcium carbonate/citrate (bone health)
Bone density · Osteoporosis · Pregnancy
Tier 1
78
Phytosterols (beta-sitosterol complex)
Cholesterol · Heart
Tier 2
76
Nicotinic acid (Niacin, flush form)
Lipids · Cardiovascular · Vitamin B3
Tier 2
75
Lactobacillus acidophilus
Gut · Vaginal health · Cholesterol
Tier 2
74
DGL Licorice (deglycyrrhizinated)
GERD · Ulcer · Gut lining
Tier 2
74
Theaflavins (black tea extract)
Cardiovascular · Cholesterol · Antioxidant
Tier 2
74
Citrulline (L-citrulline, pure form)
Blood flow · Exercise · Blood pressure
Tier 1
74
Niacinamide (nicotinamide)
Knee OA · NAD precursor · Skin · No flush · B3 form
Tier 2
74
Acacia fiber (prebiotic)
Prebiotic · IBS · Cholesterol · Bifidobacterium · Gentle · SIBO-safe
Tier 1
73
Potassium citrate
Blood pressure · Muscle · Electrolyte
Tier 1
72
Beta-glucan (1,3/1,6)
Immunity · Cholesterol · Gut
Tier 2
72
Cacao flavanols
Cardiovascular · Cognition · Blood pressure
Tier 2
71
Omega-3 (high dose)
Drug interactions · Anticoagulants · Cardiovascular
Tier 2
71
CoQ10 (ubiquinone, classic form)
Mitochondrial · Antioxidant · Statin users · Converts to ubiquinol
Tier 2
70
Lycopene
Prostate · Cardiovascular · Skin
Tier 2
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.
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