Supplements for bone
Vitamin D3, calcium, K2, magnesium — the bone-deposition triad.
Calcium and vitamin D do not prevent fractures or falls in community-dwelling adults who are not deficient. A 2026 BMJ meta-analysis of 69 trials and 153,902 adults (Massé et al., PMID 42161415, doi:10.1136/bmj-2025-088050) found a vitamin D fracture risk ratio of 1.00 (high certainty) and little to no effect on falls. Vitamin D still treats deficiency, and calcium still fills a dietary gap. Vitamin K2 (MK-7 100–200 mcg) has a separate bone-density trial, not a fracture trial. Discuss this with your provider if you have CKD or take warfarin.
Evidence summary
The numbers on the cards are the same composite as the supplement pages: efficacy, safety, research, onset, cost, and drug-interaction ratings, from 20 to 100. The strongest records on this page are Vitamin D3, Calcium, and Calcium carbonate/citrate (bone health). A higher score is a stronger record in the database, not a personal recommendation.
Who should be careful
- Pregnancy, breastfeeding, children, and anyone taking a prescription drug should talk with a clinician before using this list.
- Do not stack products from this list that sedate, thin the blood, or lower blood sugar with medicines that do the same thing.
Comparisons and topic guides
83
Vitamin D3
64
Calcium
65
Calcium carbonate/citrate (bone health)
79
Limosilactobacillus reuteri DSM 17938
77
Vitamin D3 liquid drops
74
Boswellia serrata
74
Niacinamide (nicotinamide)
74
Calcium pantothenate (Vitamin B5)
73
Vitamin K1 (phylloquinone)
72
Methylsulfonylmethane (MSM)
72
Bifidobacterium longum BB536
70
Iron
70
Lactobacillus reuteri
70
Phosphorus
70
Beta-hydroxy-beta-methylbutyrate free acid (HMB-FA)
69
Chondroitin sulfate (standalone)
68
Aged garlic extract (Kyolic)
68
L-Glutamine (post-infectious IBS)
68
Green-lipped mussel (Perna canaliculus)
66
Moringa oleifera
65
Butyrate (calcium/magnesium)
64
L-Lysine
64
Devil's claw (Harpagophytum procumbens)
64
Boswellic acids AKBA (standardised)
64
Ferulic acid
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.