Supplements for anxiety and stress
Evidence-graded picks for situational anxiety, chronic stress, and HPA-axis recovery.
L-theanine 200 mg, magnesium glycinate, lavender oil (Silexan), and saffron have the most consistent anxiety data. Ashwagandha (KSM-66 600 mg) lowers cortisol and stress markers in chronically stressed adults. Rhodiola has fatigue and stress data, particularly in shift workers. Avoid combining with SSRIs/MAOIs without prescriber input — serotonin syndrome risk. For panic disorder or moderate-severe GAD, supplements are not a substitute for evidence-based treatment.
86
L-Theanine + caffeine (cognitive stack)
82
Sodium bicarbonate (exercise buffer)
82
Magnesium glycinate
79
Magnesium bisglycinate
79
Inositol myo-form (PCOS/metabolic)
76
Tyrosine (L-tyrosine)
74
L-Theanine
74
Chamomile extract (Matricaria chamomilla)
74
Calcium pantothenate (Vitamin B5)
73
Lavender oil oral (Silexan)
72
Saffron (Crocus sativus)
72
MCT oil (medium chain triglycerides)
72
Lactobacillus casei Shirota
72
Lactobacillus helveticus/B. longum R0052/R0175
70
Bifidobacterium longum
69
Caprylic acid (C8 MCT)
69
Saffron Affron (standardised extract)
68
Ashwagandha (KSM-66)
66
L-Cysteine
65
PharmaGABA
64
Rhodiola rosea
64
Phosphatidylserine (plant-derived)
64
Ferulic acid
64
Idebenone
64
Korean red ginseng (Panax ginseng)
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.