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Supplements for vegans and vegetarians

The five nutrients plant-based diets reliably miss — and what to take instead.

Plant-based diets reliably under-deliver on five nutrients: vitamin B12 (essentially absent from plants), iron (non-heme form is 2–3× less absorbable), omega-3 EPA/DHA (algal oil is the best plant source), vitamin D3 (cholecalciferol from lichen, not D2), and zinc (lower bioavailability from grains). Calcium can be adequate from fortified plant milks but is worth tracking. Iodine deficiency is rising in vegans who avoid sea vegetables. Choline intake is lower than omnivore averages and matters in pregnancy. The list below ranks the plant-friendly supplements with the strongest published evidence for vegans and vegetarians.
88
L-Leucine (standalone)
Muscle protein synthesis · mTOR · Sarcopenia · Leucine threshold
Tier 1
82
Vitamin B12
Vegans · Elderly · Cognition
Tier 2
81
Methylcobalamin (high-dose neurological)
Neuropathy · Nerve repair · Sleep-wake cycle
Tier 2
80
L-Carnitine
Male fertility · Cardiac · Fat metabolism · Exercise recovery
Tier 1
78
Phytosterols (beta-sitosterol complex)
Cholesterol · Heart
Tier 2
77
Folic acid (synthetic)
Pregnancy · Neural tube defects · Prenatal · MTHFR consideration
Tier 2
76
Vitamin C (moderate dose)
Immunity · Collagen · Antioxidant
Tier 2
76
Ferrous bisglycinate (gentle iron)
Anaemia · Pregnancy · Iron deficiency
Tier 1
75
DHA (standalone, algal)
Brain · Pregnancy · Vegan
Tier 2
75
Pancreatin (porcine digestive enzymes)
Pancreatic insufficiency · Digestion · Fat absorption
Tier 2
75
Algal DHA (vegan omega-3)
Brain health · Pregnancy · Vegan omega-3
Tier 2
74
Pea protein
Muscle · Vegan protein · Satiety
Tier 2
74
B-complex (balanced)
Multi-B vitamin · Energy · Methylation
Tier 2
73
Vitamin A (retinol, low-dose)
Vision · Immunity · Skin
Tier 2
70
Iron
Deficiency · Fatigue · Anaemia
Tier 2
70
Tart cherry (Montmorency)
Sleep · Recovery · Inflammation
Tier 2
70
Lactoferrin
Iron absorption · Immunity · Gut
Tier 2
70
Choline bitartrate
Cognition · Liver · Methylation
Tier 2
70
Glycerol hyperhydration
Endurance · Thermoregulation · Hyperhydration
Tier 2
70
Hydroxocobalamin
B12 form · Long-acting · Cyanide antidote · Nitric oxide scavenger
Tier 2
70
Adenosylcobalamin (dibencozide)
Vitamin B12 · Mitochondrial · Energy
Tier 2
69
Rutin
Circulation · Varicose veins · Inflammation
Tier 2
68
Pelargonium sidoides (Umckaloabo)
Acute bronchitis · Cold · Respiratory
Tier 2
68
Algal oil (vegan DHA/EPA)
Omega-3 · Vegan · DHA
Tier 2
67
Iodine
Thyroid function · Deficiency
Tier 2
Educational reference, not medical advice. Discuss any supplement change with a qualified clinician before acting on this list.
See also: All symptoms · Compare two supplements · About · Methodology