Lion's mane (Hericium erinaceus, fruiting body)

Tier 3 — weak evidence · Neuroprotection · NGF · Cognition

Contains hericenones and erinacines that stimulate nerve growth factor (NGF) production in preclinical models. Docherty 2023 (Nutrients) used 1.8 g/day for 28 days in healthy adults, finding improved reaction time and reduced stress. The older Mori 2009 trial in mild cognitive impairment showed improved cognitive scores over 12 weeks that reversed on cessation. Fruiting body extracts are preferred over mycelium-on-grain products which contain mostly starch.

Dose: 1,000–3,000 mg/day fruiting body extract (hot-water or dual-extracted); avoid mycelium-on-grain products