Chasteberry/Vitex standardised (BNO 1095)

Tier 2 — promising · PMS · Menstrual regulation · Women's health

The standardised extract BNO 1095 has the strongest evidence among Vitex preparations for PMS. Pivotal RCTs of the BNO 1095 extract (Loch 2000, Schellenberg 2001 BMJ, and later replications) confirmed significant reductions in irritability, mood swings, breast tenderness, and bloating. Works by modulating dopamine and prolactin signalling. Takes 2–3 cycles to reach full effect. Avoid with dopamine agonists or oral contraceptives.

Dose: 20 mg/day BNO 1095 extract or 4 mg/day Ze 440 extract; take continuously through the full cycle