Saffron (Crocus sativus)
What it is
Saffron stigma extract (Crocus sativus) demonstrates antidepressant activity comparable to fluoxetine in mild-moderate depression. The 2025 Cheng network meta-analysis (192 trials, 17,437 patients, PMID 40314175) identified saffron as one of only four nutraceutical monotherapies with efficacy SUPERIOR to standard antidepressants (SMD 0.69, 95% CI 0.34–1.04). Standard dose is 30 mg/day of standardised extract for 6–12 weeks. Tolerability is comparable to placebo. Caution with serotonergic drugs (SSRI, MAOI, tramadol) — additive serotonin syndrome risk.
Dose
28–30 mg/day standardised saffron extract (min 2% safranal + crocin)
Time of day & tips
Take with food or water at any time of day. Do not combine with SSRIs, SNRIs, or MAOIs — serotonin syndrome risk. Allow 4–8 weeks before assessing mood effects.
Cycling
Studies typically run 6-12 weeks. Safe for continuous use at 30 mg/day based on current evidence. No established cycling protocol.
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