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Magnesium glycinate

Magnesium form · Sleep · Anxiety
Tier 1 — Strong Evidence

What it is

Magnesium chelated to two glycine molecules — the most-recommended form for sleep, anxiety, and general supplementation because the glycine ligand itself is calming (partial NMDA co-agonist and glycine receptor agonist). Superior tolerance vs oxide, citrate, and chloride — minimal laxative effect, making it the go-to form for continuous daily use at therapeutic doses. Slightly lower elemental magnesium per gram than smaller salts, but better-absorbed and far gentler on the gut.

Efficacy
4/5
Safety
5/5
Research
4/5
Onset
3/5
Cost
4/5
Drug-int.
4/5

Dose

200–400 mg elemental magnesium as glycinate, evening dose

Time of day & tips

Take 30-60 min before bed for sleep benefit; can be combined with magnesium taurate for cardio or L-threonate for cognition; very safe for long-term continuous use

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